WebBackground: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced diseases. Mechanisms underlying these diseases have been extensively studied using animal models. However, substantive differences … WebBORCS7 INFORMATION. Proteini. Full gene name according to HGNC. BLOC-1 related complex subunit 7. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BORCS7 (C10orf32, FLJ40752) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).
BORCS7 Antibody (NBP1-81912): Novus Biologicals
WebOct 12, 2024 · To replicate unique patterns of iAs methylation in humans, we generated a mouse strain in which the Borcs7/As3mt locus was humanized by syntenic replacement. The humanized mice express both full-length AS3MT that catalyzes iAs methylation and an AS3MTd2d3 splicing variant that has been linked to schizophrenia. The efficiency of iAs ... WebBackground: Chronic exposure to inorganic arsenic (iAs) is a significant public health problem. Methylation of iAs by arsenic methyltransferase (AS3MT) controls iAs detoxification and modifies risks of iAs-induced … leadership james burns
A Mutation in the Borcs7 Subunit of the Lysosome Regulatory …
WebJul 1, 2024 · Expression of Borcs7 in Tissues and Primary Cells Expression was assessed by qPCR, normalizing to 18S RNA. (A) Relative expression of Borcs7 in a number of tissues expressed as fold change ... WebLysosome function and position in the cytoplasm depends on the BORCS machinery, which tethers lysosomes to the kinesin microtubule motor. A recent paper of Snouwaert et al. in Cell Reports characterizes a mouse with a spontaneous mutation in the Borcs7 subunit, which causes axonal dystrophy and impa … WebAs part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex … leadership iv