Cisplatin prodrug

Author: zlau

August undefined, 2024

WebThe combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. However, the efficacy of this combination is limited due to the asynchronous pharmacokinetic behavior of CDDP and MET, used as free drugs. ... (HA-CDDP/PMet) dual-prodrug co-assembled nanoparticles were ... WebCyclodextrin Capped Gold Nanoparticles as a Delivery Vehicle for a Prodrug of Cisplatin Yi Shi , Jerry Goodisman , and James C. Dabrowiak * View Author Information Department of Chemistry, Syracuse University, 111 College Place, CST, Rm 1-014, Syracuse, New York 13244-4100, United States * Tel.: 315-443-4601. Fax: 315-443-4070.

Photo-Enhanced Chemotherapy Performance in Bladder Cancer …

WebNov 11, 2008 · In another report, the in vitro anticancer activity of cisplatin-encapsulated PLGA-mPEG nanoparticles was investigated against prostate cancer LNCaP cells, but the nanoparticles loaded with cisplatin showed comparable or lower activity compared with that of free cisplatin . The prodrug approach, where cisplatin is released from a Pt(IV ... WebApr 23, 2024 · Abstract. Drug resistance has always been a huge challenge that should be urgently conquered to improve the efficacy of anticancer drugs. Herein, a synergistic Pt … mark sanford hiking the appalachian trail

Emerging platinum(iv) prodrugs to combat cisplatin …

WebOct 31, 2024 · Lung cancer remains the leading cancer-associated deaths worldwide. Cisplatin (CDDP) was used in combination with curcumin (CUR) for the treatment of non-small cell lung cancer. WebTegafur is a prodrug of 5-fluorouracil (5-FU), an oral fluoropyrimidine, and it has been developed as a replacement for infusional 5-FU therapy. S-1-based chemotherapy and the combination of S-1 and cisplatin are the most reasonable first-line standards for unresectable advanced gastric cancer in Japan. ... S-1 plus cisplatin has become ... WebMay 24, 2024 · The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection in preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects of NAC are still a major challenge. mark sanford politician

National Center for Biotechnology Information

Targeted delivery of a cisplatin prodrug for safer and …

WebApr 23, 2024 · A fluorogenic cisplatin prodrug for cancer theranostics is reported, which leverages the advantages offered by in situ self-assembly with those of intracellular disassembly, which may act as a general platform for the design of prodrugs capable of improving drug delivery for cancerTheranostics. 1 PDF WebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, … navy ship apa definitionWebJun 10, 2024 · Herein, we combined a derivative of cisplatin (CP) and the chemosensitizer lonidamine (LND) to design an amphiphilic prodrug, in which the ratio of LND to cisplatin was fixed at 2:1. Diaminedichlor... navy ship american flag

"WebNov 12, 2013 · The therapeutic efficacy of NPs containing both cisplatin prodrug and REV1/REV3L-specific siRNAs was further investigated in vitro and in vivo. Quantitative real-time PCR results showed that the NPs exhibited a significant and sustained suppression of both genes in tumors for up to 3 d after a single dose. " - Cisplatin prodrug

Cisplatin prodrug

Synthesis, in vitro and Biophysical Studies of Novel Fluorescent ...

WebSep 18, 2024 · National Center for Biotechnology Information WebDec 7, 2024 · Nanoparticle-based prodrugs offer an effective strategy to improve the safety and delivery of small-molecule therapeutics while reducing the risk of drug resistance. …

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WebDec 7, 2016 · Nedaplatin is primarily used to treat head and neck, oesophagus and lung cancers. Heptaplatin ( 5, Figure 1 ), featuring malonate as its leaving group and 2- (1-methylethyl)-1,3-dioxolane-4,5-dimethanamine as its non-leaving chelating group, received approval by the Korean FDA in 1999 for the treatment of gastric cancer. WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

WebApr 1, 2014 · pH responsive cisplatin prodrug crosslinked polysaccharide-based nanoparticles were developed from succinic acid decorated dextran (Dex-SA) for active loading and triggered intracellular release of doxorubicin (DOX). Nanoparticles with uniform size were formed spontaneously in aqueous medium via electrostatic interaction … WebThis combination therapeutic approach can sensitize cancer cells to chemotherapeutics and shows superior tumor inhibition compared with monochemotherapy. Abstract Cisplatin …

WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebThe .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

WebJan 1, 2024 · Polyprodrug-based delivery technique is a fast-growing and eﬀective strategy to improve the therapeutic eﬃcacy of small molecule drugs. We herein developed a robust mitoxantrone (MTO)-based...

WebJan 9, 2014 · UGA researchers combined cisplatin with aspirin in a new single prodrug formulation they call Platin-A, which prevents these negative side effects by reducing inflammation. They reported their findings recently in Angewandte Chemie, a journal published by the German Chemical Society. “We know that inflammation plays a major … marks angry review lords mobile monster guideWebcontaining both cisplatin prodrug and REV1/REV3L-speciﬁc siRNAs was further investigated in vitro and in vivo. Quantitative real-time PCR results showed that the NPs exhibited a signiﬁcant and sustained suppression of both genes in tumors for up to 3 d after a single dose. Administering these NPs revealed a synergistic ef- marks angels cateringWebPurpose: Prodrug technology-based combination drug therapy has been exploited as a promising treatment strategy to achieve synergistic lung cancer therapy, reduce drug dose, and decrease side effects. In the present study, we synthesized a pH and glutathione (GSH) sensitive prodrug, cisplatin (CIS) and doxorubicin (DOX) conjugates (CIS-DOXp). navy ship aorWebBased on this, dibenzocyclooctyne-cisplatin (DBCO-Pt) prodrug was developed, and DCL-AAM-mediated metabolic labeling of SKOV3 cells enhanced the tumor accumulation of … navy ship anchor chain storageWebApr 2, 2024 · A combinational therapeutic modality Platin-Cbl, a prodrug of FDA-approved chemotherapeutic agents, cisplatin and chlorambucil (Cbl), was synthesized and characterized to explore the potential of this compound to initiate chemo war on cancer cells using the active drugs, cisplatin and Cbl, when delivered to the cellular power house … navy ship antietamWeb(20) Therefore, Pt (IV)-based cisplatin prodrug (DSCP) is applied to make use of the increasing GSH in cancer cells. In normal tissues and cells, Pt (IV) in DSCP is stable and shows less cytotoxicity under low GSH levels. marks angry review familiarWebFeb 28, 2024 · This review summarizes the recent advances in the synthesis of both platinum(II) and prodrugs platinum(IV) complexes for cisplatin-resistant cancer cell lines, whose therapeutic treatment still represents a great challenge. This can be correlated to the lack of selectivity toward the desired target and, therefore, the systemic side effects that ... mark sanford governor of south carolina