WebOct 25, 1985 · Cisplatin: synthesis, antitumour activity and mechanism of action. A review is presented on the successful antitumour drug cis-diamminedichloroplatinum(II), better … WebOct 5, 2014 · Carboplatin is less potent than cisplatin; depending on the type of cancer, carboplatin may only be 1/8 to 1/45 as effective. The clinical standard of dosage of carboplatin is usually a 4:1 ratio compared to cisplatin; that is, for a dose that usually requires a particular dose of cisplatin, four times more carboplatin is needed to achieve …

Platinum Anti-Cancer Drugs - Williams College

WebAdverse reactions and side effects. Compared to cisplatin, carboplatin is less emetogenic and less nephrotoxic. In dogs, the other most common adverse effects relate to gastrointestinal system toxicity (gastroenteritis, vomiting, anorexia, and diarrhea). The dose-limiting effect is myelosuppression, anemia, leukopenia, or thrombocytopenia. WebCarboplatin (Cis-diamine (1,1-cyclobutanedicarboxylato) platinum-II is mainly used to treat ovarian cancer apart from lung, head and neck cancers. It shows better antitumor activity, and it is less nephrotoxic than cisplatin, but it is more myelotoxic, i.e., depression in bone marrow than cisplatin (Wiltshaw & Kroner, 1976). sifact logo

Cisplatin: synthesis, antitumour activity and mechanism of …

WebJan 1, 2024 · Silver NPs (AgNPs) have been explored as nanocarriers owing to their good conductivity, chemical stability, and therapeutic potential. In this study, AgNPs were … WebPolycisplatin exhibited a slightly less tumor suppression effect compared with cisplatin at the low dose of 1.95 mg Pt/kg but a little better effect at higher dose of 3.9 mg Pt/kg. The body weights of mice treated with cisplatin was severely decreased even at the low dose, while body weights of mice injected with Polycisplatin did not show ... Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side … See more Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some See more Cisplatin is the square planar coordination complex cis-[Pt(NH3)2Cl2]. The prefix cis indicates the cis isomer in which two similar ligands are in adjacent positions. The systematic chemical name of this molecule is cis–diamminedichloroplatinum, where ammine with two … See more Syntheses of cisplatin start from potassium tetrachloroplatinate. Several procedures are available. One obstacle is the facile formation of Magnus's green salt (MGS), which has the … See more Cisplatin has a number of side effects that can limit its use: • Nephrotoxicity (kidney damage) is the primary dose-limiting side effect and is of major clinical concern. Cisplatin selectively accumulates into the proximal tubule via basolateral-to … See more Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water … See more The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by See more Cisplatin has been studied with Auger therapy to increase the therapeutic effects of cisplatin, without increasing normal tissue toxicities. See more sifacweb