Ddit4 hypoxia

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August undefined, 2024

WebFeb 12, 2016 · DDIT4 expression is low in physiological condition but is induced and plays an important role in hypoxia, oxidative stress, DNA damage, and other stimuli [13, 14]. It has been reported that DDIT4 can induce hypoxia-triggered apoptosis of differentiated PC12 cells through activation of the caspase pathway . DDIT4 acts as a negative regulator of mTOR, a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In particular, upregulation of HIF-1 in response to hypoxia upregulates DDIT4, leading to activation of Tsc1/2 via 14–3–3 shuttling and … See more DNA-damage-inducible transcript 4 (DDIT4) protein also known as protein regulated in development and DNA damage response 1 (REDD1) is a protein that in humans is encoded by the DDIT4 gene See more Clinical interest in DDIT4 is based primarily on its effect on mTOR, which has been associated with aging and linked with diseases such as tuberous sclerosis, See more • Ellisen LW (November 2005). "Growth control under stress: mTOR regulation through the REDD1-TSC pathway". Cell Cycle. 4 (11): 1500–02. doi:10.4161/cc.4.11.2139. PMID 16258273. • Hartley JL, Temple GF, Brasch MA (November 2000). See more • HIF1A • Tuberous sclerosis protein • MTOR • 14-3-3 protein See more

siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated …

WebDDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under the … WebAug 8, 2016 · The hypoxia response program in intestinal epithelial cells limits local inflammation 12, 27, 28, providing counter-regulation against activated neutrophils 27. Analogous to this, the... sonic black knight action figure

DDIT4 regulates mesenchymal stem cell fate by mediating …

WebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-REDD-1/DDIT4 antibody [EPR18716] (ab191871) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. Success from the first experiment – confirmed ... WebNov 23, 2016 · DDIT4 protein, human HIF1A protein, human Hypoxia-Inducible Factor 1, alpha Subunit Transcription Factors MTOR protein, human TOR Serine-Threonine Kinases Grant support Department of Health/United Kingdom Web黄丽丹;李冰玉;李亚男;王苏;龚平; 1:武汉大学人民医院麻醉科; 2:武汉大学口腔医院麻醉科口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室 smallholdings scotland for sale rightmove

DDIT4 S‐Nitrosylation Aids p38‐MAPK ... - Wiley Online Library

(PDF) A review of the mechanism of DDIT4 serve as a …

WebRegulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it … WebNov 30, 2024 · Increased levels of DDIT4 led to reduced NF-κB signalling and reduced production of pro-inflammatory cytokines and markers of oxidative stress, lipogenesis and gluconeogenesis in METTL3-KO mice... smallholdings scotland for saleWebHypoxia downregulates DIMT1, and hypoxia‐induced miR‐210 suppresses DIMT1 and IRF4 in MM To validate whether chronic hypoxia could induce reduction in DIMT1 … sonic blast man 1990 arcade all play 動画

"WebJan 8, 2024 · DDIT4 stabilizes the formation of tuberous sclerosis complex 1 (TSC1) and 2 (TSC2) to inhibit activation of the mammalian target of rapamycin (mTOR) complex (mTORC)-1, leading to cell death [7]. It seems that DDIT4 may have a tumor-suppressive role in cancer progression. " - Ddit4 hypoxia

Ddit4 hypoxia

PML nuclear bodies contribute to the basal expression of the ... - PubMed

WebFeb 21, 2024 · Given that DDIT4 function inhibits the mammalian target of rapamycin (mTOR) during stress, and DDIT4 expression promotes tumor cell apoptosis (Yang et al., 2024), we next tested if HIF3A knockdown resulted in increased HUVECs survival as monitored by decreased caspase activity during hypoxia because of reduced DDIT4 … WebJun 3, 2024 · Three genes (WAS, SETX and DDIT4) were related to DNA repair, indicating that DNA stability may be influenced by hypoxia in TNBC. Conclusions Our results demonstrate that CAIX appears to be a significant hypoxia-inducible molecular marker and increased CAIX protein levels are independently associated with poor survival in TNBC.

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WebJan 1, 2024 · In the physiological setting, DDIT4 is highly expressed in the cell cytoplasm under stress conditions such as hypoxia, cigarette smoke (76) , and UV-induced DNA damage to function as a potent... WebFeb 14, 2024 · DNA damage-inducible transcript 4 (DDIT4) has a role in human squamous cell carcinoma and is a molecular vector for the anti-carcinoma effect of 1,25(OH)2 D3 The present study clearly demonstrated that Redd1 is a therapeutic target in the development of heart failure after myocardial infarction.

WebXiaoyu Deng is an academic researcher from Zhengzhou University. The author has contributed to research in topic(s): Nasopharyngeal carcinoma & DDIT4. The author has co-authored 2 publication(s). WebDDIT4/REDD1 Rabbit Polyclonal Antibody (KO Validated) 50μl: 593.00元: 加入购物车: AF5144: CSPG4/NG2/MCSP Rabbit Polyclonal Antibody (KO Validated) 50μl: 593.00元: 加入购物车: AF5162: ENO1/Enolase-1 Rabbit Polyclonal Antibody (KO Validated) 50μl: 593.00元: 加入购物车: AF6489: c-Fos Rabbit Polyclonal Antibody: 50μl: 593.00 ...

WebJan 22, 2024 · DDIT4 is a highly conserved stress response protein whose expression is affected by various cellular stresses, such as hypoxia, DNA damage, energy stress, nutrient depletion, and endoplasmic reticulum stress [ 8 ]. WebMar 17, 2024 · DDIT4 is a mitochondrial and tumor-related protein involved in anti-tumor therapy resistance, proliferation, and invasion, etc. Its expression level increases under …

WebJul 26, 2024 · A close examination of the DDIT4 sequences between −500 and −150 revealed a conserved binding motif for hypoxia inducible factor (HIF) (Figure S8, left panel, Supporting Information). Indeed, mutagenesis of the HIF binding site abrogated induction of the DDIT4 promoter (Figure S8 , right panel, Supporting Information).

WebOur DDIT4 Antibodies can be used in a variety of model species: Human, Mouse, Rat. Use the list below to choose the DDIT4 Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Choose from our DDIT4 polyclonal antibodies. sonic blaze the cat clothes plushWebDNA damage-inducible transcript 4 (DDIT4) is a protein induced by hypoxia and in response to DNA stress. Mechanistically, DDIT4 inhibits mammalian target of … smallholdings rightmoveWebApr 8, 2016 · 此外，还发 miR一221&222 同样作用于 DNA 损伤 DDIT4调节 mTOR 通路 HCC中表达明显上调同样作用于 PTEN 由此知道miR miR一221&222 通过 PTEN ，进而影响HCC miR一423 明显促进 G1／S miR一423 p21Cipl／Wafl 发挥促生长作用。 ... etal Hypoxia —inducible microR- NA augments tatic potent ial ... sonic bleak circumstancesWebJan 8, 2024 · DDIT4 stabilizes the formation of tuberous sclerosis complex 1 (TSC1) and 2 (TSC2) to inhibit activation of the mammalian target of rapamycin (mTOR) complex (mTORC)-1, leading to cell death [ 7 ]. It seems that DDIT4 may have a tumor-suppressive role in cancer progression. sonic blast dxWebMar 21, 2024 · DDIT4 (DNA Damage Inducible Transcript 4) is a Protein Coding gene. Diseases associated with DDIT4 include Skin Atrophy and Hyperinsulinemic … smallholdings scotlandWebMar 2, 2024 · Hypoxia induces acute transactivation and repression in a HIF1A-dependent manner, but only transactivation is associated with HIF1A binding. Repressed genes are enriched for MYC targets, which... sonic blender animationWebThe DDIT4 expression is induced by multiple cellular stresses, such as hypoxia (19, 24), ionizing radiation (IR) , methyl methane sulfonate … smallholdings shropshire