Dj-1 as a therapeutic target against cancer

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WebNov 17, 2024 · DJ-1 is a gene involved in various cellular processes, including transcriptional regulation, oxidative stress response, fertilization, mitochondrial …

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WebFeb 1, 2015 · As a key regulator involved in tumor development and progression, DJ-1 has been proposed as a potential therapeutic target against cancer. Also, the development … WebIntroduction. Glioblastoma multiforme (GBM) is the most common and malignant primary brain cancer in adults. 1 Despite multimodality treatment consisting of surgical debulking, radiotherapy, and temozolomide chemotherapy, the median survival is still 12–15 months. 2 Based on successful preclinical studies, many clinical trials have tested the efficacy of … prc huren

DJ-1 as a Therapeutic Target Against Cancer. - Europe PMC

WebIntroduction : Metastatic cancers are extremely difficult to treat, and account for the vast majority of cancer-related deaths. The dissemination of tumor cells to distant sites is highly dynamic, asynchronous, and involves both tumor and host intrinsic factors. Effective therapeutic targets t … WebApr 13, 2024 · Among the most significant genes related to resistance against anti-PD-1 treatment, we identified several potentially druggable targets. ... or as a therapeutic target ... Guo J, Jia R. Histone ... WebDec 11, 2014 · Search life-sciences literature (Over 39 million articles, preprints and more) prc id date of issuance

The role of DJ-1 in the oxidative stress cell death cascade after ...

New therapeutic target discovered for a number of ... - ScienceDaily

WebJan 18, 2024 · Connexin43 as a therapeutic target against CKD Over the last years, a great effort has been made towards the discovery of novel and more efficient pharmacological targets to treat renal diseases. Cx43 has emerged as an active player in the progression of CKD, whose inhibition was proven to successfully impede the … WebEpiregulin as a therapeutic target in non-small-cell lung cancer Noriaki Sunaga,1,2 Kyoichi Kaira2,31Oncology Center, Gunma University Hospital, 2Department of Medicine and Molecular Science, 3Department of Oncology Clinical Development, Gunma University Graduate School of Medicine, Gunma, JapanAbstract: Epiregulin (EREG) belongs to the … prc id card numberWebSep 8, 2024 · The review will highlight the strengths and weaknesses of HPK1 as a candidate target for novel immuno-oncology (IO) drug development that is centered on the use of small molecule kinase inhibitor to modulate the immune response against cancer. Such a therapeutic approach, if proven successful, could supplement the cancer cell … prch spoiler tool

"WebThe administration of recombinant wild-type DJ-1 protein suppresses the neuronal loss associated with both Parkinson's disease and ischemic stroke in rats. Furthermore, in studies focused on DJ-1 as the therapeutic target, compounds that have the capacity of binding to DJ-1 at the C106 residue have been reported to exert therapeutic effects on ... " - Dj-1 as a therapeutic target against cancer

Dj-1 as a therapeutic target against cancer

DJ-1 as a human oncogene and potential therapeutic target

WebOct 1, 2024 · The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) is implicated in acquired drug resistance, metastasis, and immune suppression and has been identified as a relevant and promising target for the development of new drugs against cancer.5, 6, 7 The STAT3 signaling pathway is highly involved in the interaction ... WebSep 3, 2024 · 4. DJ-1 as a Target for Therapeutic Approaches. Due to its ability to protect from oxidative stress, DJ-1 is an interesting target for therapeutic interventions. One approach, which is the most utilized thus far in different pathological models, is to increase DJ-1 levels to obtain neuroprotection when oxidative stress arises (Figure 1).

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WebApr 23, 2024 · DJ-1, also called Parkinson’s protein 7 (PARK7), is ubiquitously expressed and plays multiple actions in different physiological and, especially, pathophysiological processes, as evidenced by its identification in neurodegenerative diseases and its high expression in different types of cancer. To date, the exact activity … WebJan 26, 2024 · Knockdown of DJ-1 synergistically inhibited AKT and ERK1/2 phosphorylation with erlotinib in pancreatic cancer cells. These findings indicate that DJ-1 may activate the RAS pathway, reinforcing erlotinib drug resistance. Therefore, blocking DJ-1 in combination with the EGFR tyrosine kinase inhibitor erlotinib may be an attractive …

WebApr 14, 2024 · Recent advances in genomics have enabled identification of cancer-enriched genome aberrations and molecular classification of cancers. For example, on the basis of copy-number variations (CNV), breast cancers have been classified into 10 integrative clusters, each with distinct outcome profiles ().Several breast cancer–enriched mutations … WebAbstract. DJ-1 is a multifaceted protein with pleiotropic functions that has been implicated in multiple diseases, ranging from neurodegeneration to cancer and ischemia-reperfusion injury. Ischemia is a complex pathological state arising when tissues and organs do not receive adequate levels of oxygen and nutrients.

WebApr 13, 2024 · Aging is a complex process of impaired physiological integrity and function, and is associated with increased risk of cardiovascular disease, diabetes, neurodegeneration, and cancer. The cellular environment of the aging brain exhibits perturbed bioenergetics, impaired adaptive neuroplasticity and flexibility, abnormal … WebCitation 105 It is shown that the combinatorial approach is superior to both siRNA-mediated DJ-1 knockdown and cisplatin treatment alone in therapeutic response, especially in the platinum-resistant A2780/cisplatin cancer cells characterized by the highest basal level of DJ-1 protein. In addition to being an anti-apoptotic agent in cancer cells ...

WebOct 10, 2006 · DJ-1's effect on Nrf2 and subsequent effects on antioxidant responses may explain how DJ-1 affects the etiology of both cancer and PD, which are seemingly disparate disorders. Furthermore, this DJ-1/Nrf2 functional axis presents a therapeutic target in cancer treatment and justifies DJ-1 as a tumor biomarker.

WebFeb 1, 2015 · As DJ-1 is a promising target for cancer therapy, while its down-regulation can serve as a potent measurement of the efficiency of chemotherapeutic and … prc id for teachersWebOct 2, 2024 · Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate. Genetic mutations and altered molecular pathways serve as targets in precise therapy. Using next-generation sequencing (NGS), these aberrant alterations can be identified and used to develop strategies that will selectively … prc human rightsWebFeb 1, 2015 · DJ-1 is a cancer- and Parkinson's disease-associated protein that participates in different intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression, oxidation, localization, and phosphorylation are often altered in human tumors, and DJ-1 has been implicated in various … prc id collectionWebAug 1, 2014 · This illustrates that DJ-1 serves as a sensitive biomarker of early protection against neurodegeneration, in response to acute hypoxic-ischemic injury, and may be … prc id exampleWebJan 12, 2024 · Novel therapeutic target in multiple myeloma. Date: January 12, 2024. Source: Institut Pasteur. Summary: Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 ... scooby doo trick or treat 123WebAug 1, 2002 · Despite the relationship between DJ-1 and cancer [18,19], the exact function of DJ-1 in cancer is yet obscure. ... DJ-1 as a human oncogene and potential therapeutic target Article pr christophe marguetWebApr 26, 2024 · The human PARK7 protein, also known as DJ-1, is a small ubiquitously expressed protein (20 kDa) comprising 189 amino acids. It is a member of the large PARK7/PfpI superfamily [] and is overexpressed in various tissues, including the testes, sperm, and the brain [2,3,4].Homozygous deletions and missense mutations in PARK7 … prc id renewal requirements 2022