Epha2 phosphorylation

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August undefined, 2024

WebApr 30, 2024 · Depletion of EphA2 promotes inflammasome activation upon infection and aggravates ovalbumin-induced asthma. EphA2 binds to NLRP3 and induces its phosphorylation, thereby blocking inflammasome assembly and activation. Conflict of interest The authors declare that they have no conflict of interest. References WebJan 22, 2024 · It has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic entry, EphA2 is phosphorylated at …

Signalling inhibition by ponatinib disrupts productive alternative ...

WebInhibiting ligand-independent EphA2 phosphorylation suppresses the growth of SCLC in vitro and in vivo. To further investigate whether chemoresistance of SCLC would be affected only when the catalytic activities of EphA2 and PRMT1 were inhibited, a small molecule inhibitor of EphA2, ALW-II-41-27, and small molecule inhibitor of PRMT1, AMI-1 ... WebEphA2 can be phosphorylated on S897 by the RSK, AKT and PKA kinases to promote a non-canonical form of signaling that plays an important role in cancer … east surrey ymca

EPHA2 Is a Predictive Biomarker of Resistance and a Potential ...

WebNational Center for Biotechnology Information WebApr 20, 2024 · In T47D EphA2 cells, EA5 binding to EphA2 can block E2-mediated phosphorylation of FAKY925, thereby increasing the sensitivity of the ER to tamoxifen (Gökmen-Polar et al., 2011) (Fig. 2). Trastuzumab is the primary treatment for HER2 + breast cancer patients. EphA2 also causes natural and acquired resistance. WebAug 27, 2024 · EphA2 is an important oncogenic protein and emerging drug target, but the oncogenic role and mechanism of ligand-independent phosphorylation of EphA2 at … cumberland plain conservation plan mapping

EphA2 phosphorylates NLRP3 and inhibits inflammasomes in …

Regulation of the EphA2 receptor intracellular region by …

WebEphA2, a member of the Eph receptor tyrosine kinases, is frequently overexpressed in a variety of malignancies, including glioblastoma, and its expression is correlated with poor prognosis. EphA2 acts as a tumor promoter through a ligand ephrin-independent mechanism, which requires phosphorylation o … east sussex and kent railwayWebDec 2, 2024 · Surprisingly, EphA2 S897E, with mutation of the functionally best characterized linker phosphorylation site, shows the weakest HDX differences in these regions (Fig. 5e), suggesting that ... east sussex adopted road

"WebEPHA2. A gene on chromosome 1q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound … " - Epha2 phosphorylation

Epha2 phosphorylation

Protein kinase C phosphorylates the EphA2 receptor on …

WebWe show that the ephrin receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV gH-gL. EphA2 co-precipitated with both gH-gL and KSHV virions. Infection of human epithelial cells with a GFP-expressing recombinant KSHV strain, as measured by FACS analysis, was increased upon overexpression of EphA2. WebApr 1, 2024 · EPHA2 was differentially activated in colorectal cancer cell lines. Combined treatment with ALW-II-41-27 plus cetuximab reverted primary and acquired resistance to …

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WebJan 20, 2024 · Densitometric analysis of 3 EphA2 and EGFR phosphorylation (Y1068) (A) and total EphA2 and EGFR levels (B) in oral epithelial cells that had been infected with the indicated C. albicans strains for 30 and 90 min. Results are combined data from 3 immunoblots. Images of representative immunoblots are shown in Fig 2A. WebJul 1, 2009 · EphA2 is a representative member of a 16 member superfamily of receptor tyrosine kinases (RTK). The corresponding ligands for Eph RTKs, called ephrins, are anchored on the plasma membrane through either a glycophosphatidylinositol linkage (ephrin-A) or through a transmembrane domain (ephrin-B).

WebProgranulin evoked Akt- and Erk1/2-mediated EphA2 phosphorylation at Ser897, which could drive bladder tumorigenesis. We discovered that EphA2 depletion severely blunted progranulin-dependent motility and anchorage-independent growth, and sensitized bladder cancer cells to cisplatin treatment. Web2024年. Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis. Filamin A forms a complex with EphA2 and regulates EphA2 serine 897 phosphorylation and glioblastoma cell proliferation. Tamura Y., Nakamizo Y., Watanabe Y., Kimura I., Katoh, H. Biochem.

WebNov 3, 2024 · EphA2 interacts with PLCγ1 and the kinase activity of EphA2 was required for phosphorylation of PLCγ1. In human lung cancer cells, genetic or pharmacologic inhibition of EphA2 decreased phosphorylation of PLCγ1 and loss of … WebMar 12, 2024 · EphA2 activates cytoplasmic tyrosine phosphatase leading to auto-phosphorylation and tyrosine phosphorylation of a large number of downstream intracellular substrate protein molecules and...

WebSep 1, 2024 · EphA2 expression is required for efficient elongation of tensin- and α5β1-rich fibrillar adhesions in vascular smooth muscle cells. • EphA2 undergoes ligand …

WebNov 7, 2013 · Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase Shp2 is a positive regulator for Erk activation downstream of receptor tyrosine kinases for growth factors. It has been controversial how Shp2 induces Erk activation. cumberland plain woodland final determinationWebIt has been known that EphA2 is phosphorylated at Tyr588, which is triggered by the ligand binding, and at Ser897 downstream of growth factor signaling. Upon mitotic … east surrey redhill hospitalWebMay 6, 2011 · Upstream of the EphA2 phosphorylation, activation of Akt1 on Ser 129 was also revealed as part of the ephrin B3-mediated signaling pathway. Phosphorylation of these sites was further confirmed by immune-based strategies in … east sussex beekeepers associationWebSep 1, 2024 · The EphA2 receptor tyrosine kinase signals through two distinct mechanisms, one regulated by tyrosine phosphorylation and the other by serine/threonine phosphorylation. Serine 892 (S892) is one of the major serine/threonine phosphorylation sites in EphA2, but little is known about its regulation and function. east sussex annual review paperworkWebThis study evaluated tumour dependency on oncogenic EphA2 receptor regulation and VM in invasive carcinoma of the breast and their prognostic significance. ... Phosphorylation of EphA2 receptor and vasculogenic mimicry is an indicator of poor prognosis in invasive carcinoma of the breast Breast Cancer Res Treat. 2024 Jan;179(2):359-370. doi: 10 ... east sushi rollWebAug 18, 2024 · Under normal conditions, cell–cell contacts allow EphA2 to interact with ephrin A1, which induces EphA2 phosphorylation and activates its downstream signaling. Tyrosine phosphorylation of EphA2 promotes the generation of a complex … east sussex blue badge schemeWebMar 1, 2024 · As phosphorylation of Stat3 at S727 leads to its transcriptional activation [43], we performed a dual luciferase reporter assay to determine the effect of pS897 … east sussex blue badge renewal