Web15 jun. 2024 · Ashcroft scoring utilizes a numerical scale from 0 through 8 to grade fibrosis; it is subject to intra- and inter-scorer variability ( 20 ). Computerized digital image analysis was developed to utilize a continuous measure of fibrosis in various rodent or human tissues, including lung, liver, heart, and kidney ( 21 – 28 ). WebOATD-01 exhibited significant anti-fibrotic activity, comparable to pirfenidone, as assessed by the modified Ashcroft scale and significant reduction in lung weight. The anti-fibrotic effects of OATD-01 correlated with suppression of the bleomycin-induced chitinolytic activity in plasma (4h after last dose) confirming target engagement.
Interrater Reliability of a Modified Ashworth Scale of Muscle ...
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Standardized quantification of pulmonary fibrosis in histological ...
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