Nphs1-cre

Author: idqa

August undefined, 2024

Web3 sep. 2014 · Podocyte-specific deletion of Tjp1 results in glomerulosclerosis. (A) Kidney sections from Tjp1 flox/flox and Nphs1-Cre: Tjp1 flox/flox mice were examined with the antibody against Tjp1. WebTg (Nphs1-cre)33Mska Transgene Detail MGI Mouse (MGI:3762483) Search Genes More Phenotypes Phenotypes, Alleles & Diseases Query Mammalian Phenotype (MP) Browser More All MGI Reports Batch Query Genes & Markers Gene Ontology Data Gene …

Tg (Nphs1-cre)33Mska Transgene Detail MGI Mouse (MGI:3762483)

WebThe NPHS1 gene, mapped at chromosome 19q13.1, encodes nephrin, a podocyte protein. Nephrin and podocin may interact directly or indirectly and are important for maintenance of the glomerular ... Web86. The Jackson Laboratory nphs2 also known as podocin cre mice. Nphs2 Also Known As Podocin Cre Mice, supplied by The Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, … skechers cyber monday sale

Podocyte-specific expression of tamoxifen-inducible Cre …

WebFlt1 allele, and the Nphs1-Cre transgene (Nphs1-Cre+Flt1ﬂox/TK). These mice can express full-length Flt1 as well as sFlt1 in all tissues except podocytes, in which the ﬂoxed allele is inacti-vated,leavingonlyFlt1TK.Outof33animalsthatwereexamined, the majority (n … Web基本信息. 品系说明：表达系统/组织：泌尿生殖系统；详见品系资料。. 理论标记细胞类型：肾小球，肾足细胞；未进行细胞层面验证。. 基因官方名：Nphs1,iCre. 基因全名：nephrosis 1, nephrin. 基因别名：NephrinB,nephrin. NCBI： 54631. MGI： 1859637. … WebNormal Function. The NPHS1 gene provides instructions for making a protein called nephrin. Nephrin is primarily found in the kidneys, which are organs that filter waste products from the blood and remove them in urine. Specifically, nephrin is found in cells called … skechers cyclers

Nephrin - Wikipedia

WebNphs1-Cre+Flt1flox/flox Reorganization of podocyte cytoskeleton, Kidney failure (35) Vegfr-1/Flt-1 germline TM domain knockout Flt-1TM-TK/TM-TK Reduced vascular development, death at E8.5 in some embryos (21) Vegfr-2/Flk-1 germline knockout with lacZ reporter Flk-1−/− (Flk-1lcz/lcz) Lack of vascular development, lethality at E8.5-9.5 (14 ... WebNS in Newborns and Children Nephrin is a podocyte protein and a major component of the SD. Mutations in the nephrin gene (NPHS1) causes congenital nephrotic syndrome of the Finnish type (CNF, NPHS1), which is an autosomal recessive disease accounting for about half of cases with congenital NS. suwannee thai cuisine kearneyWebof Cre recombinase, they express IjBDN, which lacks its N-terminal of 54 amino acids including 2 phosphorylation sites at serines 32 and 36, thereby continuously inhibiting NF-jB activation as a super-repressor. In the present study, podocyte-speciﬁc IjBDN … suwannee tax collector

"Web1 jan. 2014 · For genetic podocyte tagging, we mated Nphs1-Cre/ROSA26-loxP mice with NEP25 mice to obtain Nphs1-Cre/ROSA26-loxP/NEP25 triple transgenic mice, in which we were able to monitor the podocyte lineage by means of β-galactosidase expression. " - Nphs1-cre

Nphs1-cre

Notch1 and Notch2 in Podocytes Play Differential Roles During …

Webdevelopment of slit diaphragms [22] and Nphs1-Cre-mediated recombination cannot be accomplished before the onset of slit diaphragm formation (data not shown). At P7–10, however, we observed apically dislocated slit diaphragms and foot process effacement. … WebThe Nphs1-Cre transgene mediates podocyte-specific recombination. (A)Podocyte-specific recombination of loxP-flanked regions mediated by the Nphs1-Cre transgene. Red triangles represent loxP sequences. (B)Specific Cre activity restricted to the glomeruli was confirmed in the kidneys of Rosa26R reporter mice carrying the Nphs1-Cre transgene. X-gal …

Did you know?

Web15 jun. 2024 · Inducible, podocyte-specific Epb41l5 knockout (KO) mice (Epb41l5 fl/fl *Nphs1-rtTA-3G*tetOCre) were generated using a previously described Epb41l5 fl/fl allele in combination with a podocyte-specific, inducible Cre line (Nphs1-rtTA-3G (syn. NEFTA)). … Web18 jan. 2024 · Nphs1-RiboTag and Nphs1-RiboTag-NEP25 mice without LMB2 showed a normal UACR of 0.085 mg/mg [95% confidence interval (CI) 0.076–0.096] and normal renal morphology. Glomeruli were isolated from Nphs1-RiboTag mice, homogenized, and …

WebNephrin, encoded by podocyte-specific NPHS1 gene, participated in the pathogenesis of FSGS. Thirty-two genetic mutations of NPHS1 gene were identified in FSGS patients, including 12 synonymous mutations, 17 missense mutations, 1 splicing mutation, and 2 … Web21 mrt. 2024 · NPHS2 (NPHS2 Stomatin Family Member, Podocin) is a Protein Coding gene. Diseases associated with NPHS2 include Nephrotic Syndrome, Type 2 and Nephrotic Syndrome . Among its related pathways are Cell junction organization and Nephrin family interactions . An important paralog of this gene is STOM. UniProtKB/Swiss-Prot …

WebAverage 86 stars, based on 1 article reviews Price from $9.99 to $1999.99 rat anti zo 1 - by Bioz Stars , 2024-03 86 / 100 stars Images 1) Product Images from "Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors" Web14 mrt. 2024 · cyte-speciﬁc Cre-expressing line (Nphs1-Cre) (Fig. 1A), then combined with our NEP25 line. Utilizing these mice, we performed global translatome analyses in both normal and injured podocytes. MATERIALS AND METHODS Animal experiments. The …

WebTamoxifen诱导Cre-ERT2小鼠使用指南. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。查看

Web14 jan. 2009 · Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. suwannee tides for fishingWeb人类的NPHS1是先天性肾病综合征芬兰型 (congenital nephrotic syndrome，Finnish type，CNF)致病基因代码。. 1998年，Kestila等利用定位克隆技术，发现NPHS1是CNF致病基因，位于常染色体19q12 – q13.1，编码nephrin。. nephrin属于细胞黏附分子免疫球蛋 … skechers cypress big plansWebJ-GLOBAL ID：200902212109484333 整理番号：08A0528537 Nphs1-Cre/ROSA26-loxP遺伝学的有足細胞標識は,FSGSを伴う実験的腎症のp21欠失マウスにおいて壁細胞増殖を示した suwannee thai kearney neWebThe NPHS1 gene mutated in NPHS1 children has recently been identified. The gene codes for nephrin, a cell-surface protein of podocytes. Two mutations, named Fin-major and Fin-minor, have been found in over 90% of the Finnish patients. suwannee thai spaWeb1 mei 2009 · In all cells of the podocyte lineage in Nphs1-Cre/ROSA26 mice, the lacZ marker gene is irreversibly activated after Cre-mediated excision by nephrin promoter activation.Thus, podocyte lineage cells are theoretically stably labeled with lacZ, even when they are injured and lose podocyte markers. skechers cypress big plans bootWeb（NPHS1）プロモーターに隣接してCreリコンビナーゼを発現したNphs1-Creマウスと、flox配列をもつ Extl3 flox/flox マウスを交配させることで、糸球体足細胞選択的なExtl3のノックアウトをおこなった。 suwannee to johns creek distanceWebIntroduction: Few studies have addressed the genetic spectrum of NPHS1 variants in Chinese children with nephrotic syndrome. In this multicenter study, the clinical manifestations and features of NPHS1 variants in Chinese children with nephrotic … suwannee thai spa bellevue